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Proceedings Paper

Effective connectivity of neural pathways underlying disgust by multivariate Granger causality analysis
Author(s): Hao Yan; Yonghui Wang; Jie Tian; Yijun Liu
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Paper Abstract

The disgust system arises phylogenetically in response to dangers to the internal milieu from pathogens and their toxic products. Functional imaging studies have demonstrated that a much wider range of neural structures was involved in triggering disgust reactions. However, less is known regarding how and what neural pathways these neural structures interact. To address this issue, we adopted an effective connectivity based analysis, namely the multivariate Granger causality approach, to explore the causal interactions within these brain networks. Results presented that disgust can induce a wide range of brain activities, such as the insula, the anterior cingulate cortex, the parahippocampus lobe, the dorsal lateral prefrontal cortex, the superior occipital gyrus, and the supplementary motor cortex. These brain areas constitute as a whole, with much denser connectivity following disgust stimuli, in comparison with that of the neutral condition. Moreover, the anterior insula, showing multiple casual interactions with limbic and subcortical areas, was implicated as a central hub in organizing multiple information processing in the disgust system.

Paper Details

Date Published: 9 March 2011
PDF: 9 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 796504 (9 March 2011); doi: 10.1117/12.877642
Show Author Affiliations
Hao Yan, Shaanxi Normal Univ. (China)
Xidian Univ. (China)
Peking Univ. (China)
Yonghui Wang, Shaanxi Normal Univ. (China)
Jie Tian, Institute of Automation (China)
Xidian Univ. (China)
Yijun Liu, Peking Univ. (China)
Univ. of Florida (United States)

Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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