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Proceedings Paper

3D diffraction tomography for visualization of contrast media
Author(s): Vinay M. Pai; Ashley Stein; Megan Kozlowski; Ashvin George; Rael Kopace; Eric Bennett; Julie A. Auxier; Han Wen
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Paper Abstract

In x-ray CT, the ability to selectively isolate a contrast agent signal from the surrounding soft tissue and bone can greatly enhance contrast visibility and enable quantification of contrast concentration. We present here a 3D diffraction tomography implementation for selectively retaining volumetric diffraction signal from contrast agent particles that are within a banded size range while suppressing the background signal from soft tissue and bone. For this purpose, we developed a CT implementation of a single-shot x-ray diffraction imaging technique utilizing gratings. This technique yields both diffraction and absorption images from a single grating-modulated projection image through analysis in the spatial frequency domain. A solution of iron oxide nano-particles, having very different x-ray diffraction properties from tissue, was injected into ex vivo chicken wing and in vivo rat specimens respectively and imaged in a 3D diffraction CT setup. Following parallel beam reconstruction, it is noted that while the soft tissue, bone and contrast media are observed in the absorption volume reconstruction, only the contrast media is observed in the diffraction volume reconstruction. This 3D diffraction tomographic reconstruction permits the visualization and quantification of the contrast agent isolated from the soft tissue and bone background.

Paper Details

Date Published: 16 March 2011
PDF: 7 pages
Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 79611K (16 March 2011); doi: 10.1117/12.877390
Show Author Affiliations
Vinay M. Pai, National Institutes of Health (United States)
Ashley Stein, Harvard Medical School (United States)
Megan Kozlowski, National Institutes of Health (United States)
Ashvin George, National Institutes of Health (United States)
Rael Kopace, Duke Univ. (United States)
Eric Bennett, National Institutes of Health (United States)
Julie A. Auxier, Oregon State Univ. (United States)
Han Wen, National Institutes of Health (United States)

Published in SPIE Proceedings Vol. 7961:
Medical Imaging 2011: Physics of Medical Imaging
Norbert J. Pelc; Ehsan Samei; Robert M. Nishikawa, Editor(s)

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