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Proceedings Paper

Real-time fMRI data analysis using region of interest selection based on fast ICA
Author(s): Baoquan Xie; Xinyue Ma; Li Yao; Zhiying Long; Xiaojie Zhao
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Paper Abstract

Real-time functional magnetic resonance imaging (rtfMRI) is a new technique which can present (feedback) brain activity during scanning. Through fast acquisition and online analysis of BOLD signal, fMRI data are processed within one TR. Current rtfMRI provides an activation map under specific task mainly through the GLM analysis to select region of interest (ROI). This study was based on independent component analysis (ICA) and used the result of fast ICA analysis to select the node of the functional network as the ROI. Real-time brain activity within the ROI was presented to the subject who needed to find strategies to control his brain activity. The whole real-time processes involved three parts: pre-processing (including head motion correction and smoothing), fast ICA analysis and feedback. In addition, the result of fast head motion correction was also presented to the experimenter in a curve diagram. Based on the above analysis processes, a real time feedback experiment with a motor imagery task was performed. An overt finger movement task as localizer session was adopted for ICA analysis to get the motor network. Supplementary motor area (SMA) in such network was selected as the ROI. During the feedback session, the average of BOLD signals within ROI was presented to the subjects for self-regulation under a motor imagery task. In this experiment, TR was 1.5 seconds, and the whole time of processing and presentation was within 1 second. Experimental results not only showed that the SMA was controllable, but also proved that the analysis method was effective.

Paper Details

Date Published: 9 March 2011
PDF: 7 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79651S (9 March 2011); doi: 10.1117/12.877141
Show Author Affiliations
Baoquan Xie, Beijing Normal Univ. (China)
Xinyue Ma, Beijing Normal Univ. (China)
Li Yao, Beijing Normal Univ. (China)
Zhiying Long, Beijing Normal Univ. (China)
Xiaojie Zhao, Beijing Normal Univ. (China)

Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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