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Proceedings Paper

Photothermal ablation of malignant brain tumors by nanoparticle loaded macrophages
Author(s): Henry Hirschberg; Seung-Kuk Baek; Young Jik Kwon; Chung-Ho Sun; Steen J. Madsen
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Paper Abstract

Nanoshells are a new class of optically tunable nanoparticles composed of a dielectric core (silica) coated with an ultrathin metallic layer (gold). Since nanoshells are roughly one million times more efficient at converting NIR light into heat than conventional dyes when exposed to NIR light, they can generate sufficient heat to induce cell death. Macrophages are frequently found in and around glioblastomas in both experimental animals and patient biopsies. Inflammatory cells loaded with nanoparticles could therefore be used to target tumors.

Paper Details

Date Published: 18 February 2011
PDF: 10 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78833U (18 February 2011); doi: 10.1117/12.876224
Show Author Affiliations
Henry Hirschberg, Beckman Laser Institute (United States)
Univ. of Nevada (United States)
Seung-Kuk Baek, Beckman Laser Institute (United States)
Korea Univ. College of Medicine (Korea, Republic of)
Young Jik Kwon, Univ. of California, Irvine (United States)
Chung-Ho Sun, Beckman Laser Institute (United States)
Steen J. Madsen, Beckman Laser Institute (United States)
Univ. of Nevada, Las Vegas (United States)

Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory M.D.; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg M.D.; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong M.D.; Justus F. R. Ilgner M.D.; Bodo E. Knudsen M.D.; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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