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Proceedings Paper

Fluorescence-guided surgical resection of oral cancer reduces recurrence
Author(s): Pierre Lane; Catherine F. Poh; J. Scott Durham; Lewei Zhang; Sylvia F. Lam; Miriam Rosin; Calum MacAulay
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Paper Abstract

Approximately 36,000 people in the US will be newly diagnosed with oral cancer in 2010 and it will cause 8,000 new deaths. The death rate is unacceptably high because oral cancer is usually discovered late in its development and is often difficult to treat or remove completely. Data collected over the last 5 years at the BC Cancer Agency suggest that the surgical resection of oral lesions guided by the visualization of the alteration of endogenous tissue fluorescence can dramatically reduce the rate of cancer recurrence. Four years into a study which compares conventional versus fluorescence-guided surgical resection, we reported a recurrence rate of 25% (7 of 28 patients) for the control group compared to a recurrence rate of 0% (none of the 32 patients) for the fluorescence-guided group. Here we present resent results from this ongoing study in which patients undergo either conventional surgical resection of oral cancer under white light illumination or using tools that enable the visualization of naturally occurring tissue fluorescence.

Paper Details

Date Published: 17 February 2011
PDF: 6 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832X (17 February 2011); doi: 10.1117/12.876062
Show Author Affiliations
Pierre Lane, British Columbia Cancer Research Ctr. (Canada)
Catherine F. Poh, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada)
Vancouver General Hospital (Canada)
J. Scott Durham, Vancouver General Hospital (Canada)
Lewei Zhang, Univ. of British Columbia (Canada)
Vancouver General Hospital (Canada)
Sylvia F. Lam, British Columbia Cancer Research Ctr. (Canada)
Miriam Rosin, British Columbia Cancer Research Ctr. (Canada)
Simon Fraser Univ. (Canada)
Calum MacAulay, British Columbia Cancer Research Ctr. (Canada)

Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory M.D.; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg M.D.; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong M.D.; Justus F. R. Ilgner M.D.; Bodo E. Knudsen M.D.; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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