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Proceedings Paper

Analysis and classification of optical tomographic images of rheumatoid fingers with ANOVA and discriminate analysis
Author(s): Ludguier D. Montejo; Hyun K. Kim; Yrjö Häme; Jingfei Jia; Julio D. Montejo; Uwe J. Netz; Sabine Blaschke; Paul Zwaka; Gerhard A. Müeller; Jürgen Beuthan; Andreas H. Hielscher
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Paper Abstract

We present a study on the effectiveness of computer-aided diagnosis (CAD) of rheumatoid arthritis (RA) from frequency-domain diffuse optical tomographic (FDOT) images. FDOT is used to obtain the distribution of tissue optical properties. Subsequently, the non-parametric Kruskal-Wallis ANOVA test is employed to verify statistically significant differences between the optical parameters of patients affected by RA and healthy volunteers. Furthermore, quadratic discriminate analysis (QDA) of the absorption (μa) and scattering (μa or μ's) distributions is used to classify subjects as affected or not affected by RA. We evaluate the classification efficiency by determining the sensitivity (Se), specificity (Sp), and the Youden index (Y). We find that combining features extracted from μa and μa or μ's images allows for more accurate classification than when μa or μa or μ's features are considered individually on their own. Combining μa and μa or μ's features yields values of up to Y = 0.75 (Se = 0.84 and Sp = 0.91). The best results when μa or μ's features are considered individually are Y = 0.65 (Se = 0.85 and Sp = 0.80) and Y = 0.70 (Se = 0.80 and Sp = 0.90), respectively.

Paper Details

Date Published: 21 February 2011
PDF: 6 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900L (21 February 2011); doi: 10.1117/12.875977
Show Author Affiliations
Ludguier D. Montejo, Columbia Univ. (United States)
Hyun K. Kim, Columbia Univ. (United States)
Yrjö Häme, Columbia Univ. (United States)
Jingfei Jia, Columbia Univ. (United States)
Julio D. Montejo, Harvard Univ. (United States)
Uwe J. Netz, Laser- und Medizin-Technologie GmbH, Berlin (Germany)
Sabine Blaschke, Universitätsmedizin Göttingen (Germany)
Paul Zwaka, Universitätsmedizin Göttingen (Germany)
Gerhard A. Müeller, Universitätsmedizin Göttingen (Germany)
Jürgen Beuthan, Laser- und Medizin-Technologie GmbH, Berlin (Germany)
Andreas H. Hielscher, Columbia Univ. (United States)
Columbia Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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