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Proceedings Paper

Toward in-vivo photoacoustic imaging of human ovarian tissue for cancer detection
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Paper Abstract

Currently, most of the cancers in the ovary are detected when they have already metastasized to other parts of the body. As a result, ovarian cancer has the highest mortality of all gynecological cancers with a 5-year survival rate of 30% or less [1]. The reason is the lack of reliable symptoms as well as the lack of efficacious screening techniques [2,3]. Thus, there is an urgent need to improve the current diagnostic techniques. We have investigated the potential role of co-registered photoacoustic and ultrasound imaging in ovarian cancer detection. In an effort to bring this technique closer to clinical application, we have developed a co-registered ultrasound and photoacoustic transvaginal probe. A fiber coupling assembly has been developed to deliver the light from around the transducer for reflection geometry imaging. Co-registered ultrasound and photoacoustic images of swine ovaries through vagina wall muscle and human ovaries using the aforementioned probe, demonstrate the potential of photoacoustic imaging to non-invasively detect ovarian cancer in vivo.

Paper Details

Date Published: 17 February 2011
PDF: 6 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789908 (17 February 2011); doi: 10.1117/12.875950
Show Author Affiliations
Andres Aguirre, Univ. of Connecticut (United States)
Patrick Kumavor, Univ. of Connecticut (United States)
Yasaman Ardeshirpour, Univ. of Connecticut (United States)
Mary M. Sanders, Univ. of Connecticut Health Ctr. (United States)
Molly Brewer, Univ. of Connecticut Health Ctr. (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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