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Proceedings Paper

Effects of LED phototherapy on bone defects grafted with MTA, bone morphogenetic proteins, and guided bone regeneration in a rodent model: a description of the bone repair by light microscopy
Author(s): Antonio Luiz B. Pinheiro; Gilberth T. S. Aciole; Luiz G. P. Soares; Neandder A. Correia; Jean N. dos Santos
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Paper Abstract

We carried out a histological analysis on surgical bone defects grafted or not with MTA, treated or not with LED, BMPs and GBR. We have used several models to assess the effects of laser on bone. Benefits of the isolated or combined use them on bone healing has been suggested. There is no previous report on their association with LED light. 90 rats were divided into 10 groups. On Groups II and I the defect were filled with the clot. On Group II, were further irradiated. On groups III-VI, defect was filled with MTA + Collagen gel (III); animals of group IV were further irradiated. On groups V and VI, the defects filled with the MTA were covered with a membrane. Animals of Group VI were further irradiated. On Groups VII and VIII a pool of BMPs was added to the MTA and was further irradiated. On groups IX and X, the MTA + BMP graft was covered with a membrane. On group X, the defect was further irradiated. LED (λ850 ± 10nm, 150mW, A= 0.5cm2, 54s, 0.3W/cm2, 16 J/cm2) was applied at 48 h intervals during 15 days. Specimens were taken, processed, cut and stained with H&E and Sirius red and underwent histological analysis. The results showed that MTA seemed not being affected by LED light. However, its use positively affected healing around the graft. It is concluded that MTA is not affected by the LED light due to it characteristics, but beneficial results with LED usage was found.

Paper Details

Date Published: 17 February 2011
PDF: 7 pages
Proc. SPIE 7887, Mechanisms for Low-Light Therapy VI, 78870F (17 February 2011); doi: 10.1117/12.875836
Show Author Affiliations
Antonio Luiz B. Pinheiro, Federal Univ. of Bahia (Brazil)
Camilo Castelo Branco Univ. (Brazil)
National Institute of Optics and Photonics (Brazil)
Gilberth T. S. Aciole, Federal Univ. of Bahia (Brazil)
Luiz G. P. Soares, Federal Univ. of Bahia (Brazil)
Neandder A. Correia, Federal Univ. of Bahia (Brazil)
Jean N. dos Santos, National Institute of Optics and Photonics (Brazil)
Federal Univ. of Bahia (Brazil)

Published in SPIE Proceedings Vol. 7887:
Mechanisms for Low-Light Therapy VI
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

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