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Proceedings Paper

MRI-guided fluorescence tomography of PPIX in the breast: a case study
Author(s): Scott C. Davis; Michael A. Mastanduno; Brian W. Pogue; Keith D. Paulsen
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Paper Abstract

A case study to demonstrate fluorescence tomography of endogenous protoporphyrin IX (PPIX) in breast cancer is presented. An MRI-coupled fluorescence tomography system with spectrometer detectors was used to acquire excitation and emission data through the breast of a human subject undergoing chemotherapy for breast cancer. Volumetric images of PPIX fluorescence showed elevated levels of fluorescence activity in the fibro-glandular tissue as compared to the adipose tissue. Fluorescence levels in the tumor were higher than in the adipose tissue but lower than the fibro-glandular tissue.

Paper Details

Date Published: 10 February 2011
PDF: 5 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920M (10 February 2011); doi: 10.1117/12.875775
Show Author Affiliations
Scott C. Davis, Dartmouth College (United States)
Michael A. Mastanduno, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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