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Proceedings Paper

Inertial microfluidics for continuous separation of cells and particles
Author(s): Arpita Chatterjee; Sathyakumar S. Kuntaegowdanahalli; Ian Papautsky
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Paper Abstract

In this work we describe the use of inertial microfluidics for continuous multi-particle separation in a simple spiral microchannel. The inertial forces coupled with the rotational Dean drag force in the spiral microchannel geometry cause neutrally-buoyant particles and cells to occupy a single equilibrium position near the inner microchannel wall. This position is strongly dependent on the particle/cell diameter. Based on this concept, a 5-loop Archimedean spiral microchannel chip was used to demonstrate for the first time focusing and separation of four particles simultaneously. The polystyrene particles (7.32 μm, 10 μm, 15 μm, 20 μm in diameter) were selected for this work since they are compatible to the size of blood cells. The device exhibited an average 87% separation efficiency, which is comparable to that of other microfluidic separation systems. The simple planar structure and high sample throughput offered by this passive microfluidic approach makes it attractive for lab-on-a-chip integration in hematology applications.

Paper Details

Date Published: 14 February 2011
PDF: 10 pages
Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 792907 (14 February 2011); doi: 10.1117/12.875774
Show Author Affiliations
Arpita Chatterjee, Univ. of Cincinnati (United States)
Sathyakumar S. Kuntaegowdanahalli, Univ. of Cincinnati (United States)
Ian Papautsky, Univ. of Cincinnati (United States)

Published in SPIE Proceedings Vol. 7929:
Microfluidics, BioMEMS, and Medical Microsystems IX
Holger Becker; Bonnie L. Gray, Editor(s)

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