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Proceedings Paper

Millimeter wave-induced changes in membrane properties of leech Retzius neurons
Author(s): Victor Pikov; Peter H. Siegel
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Paper Abstract

This study evaluated a novel method for modulation of neuronal excitability using non-invasive delivery of millimeter waves. Millimeter waves at 60 GHz and incident power density of 100-600 μW/cm2 were applied to three intact segmental ganglia of the adult leach, and intracellular neuronal activity was recorded from the Retzius neurons using intracellular glass electrode. Transient dosedependent increase in the plasma membrane permeability was observed. In addition, in one of the examined neurons, a decrease in the neuronal firing rate was also evident. The results provide strong evidence for the feasibility of modulating neuronal excitability using non-invasive delivery of millimeter waves, and will be explored further for applications in basic neuroscience and treatment of neurological disorders.

Paper Details

Date Published: 18 February 2011
PDF: 5 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788356 (18 February 2011); doi: 10.1117/12.875758
Show Author Affiliations
Victor Pikov, Huntington Medical Research Institutes (United States)
Univ. of Southern California, Los Angeles (United States)
Peter H. Siegel, California Institute of Technology (United States)

Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory M.D.; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg M.D.; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong M.D.; Justus F. R. Ilgner M.D.; Bodo E. Knudsen M.D.; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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