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Proceedings Paper

Photoacoustic imaging to detect rat brain activation after cocaine hydrochloride injection
Author(s): Janggun Jo; Xinmai Yang
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Paper Abstract

Photoacoustic imaging (PAI) was employed to detect small animal brain activation after the administration of cocaine hydrochloride. Sprague Dawley rats were injected with different concentrations (2.5, 3.0, and 5.0 mg per kg body) of cocaine hydrochloride in saline solution through tail veins. The brain functional response to the injection was monitored by photoacoustic tomography (PAT) system with horizontal scanning of cerebral cortex of rat brain. Photoacoustic microscopy (PAM) was also used for coronal view images. The modified PAT system used multiple ultrasonic detectors to reduce the scanning time and maintain a good signal-to-noise ratio (SNR). The measured photoacoustic signal changes confirmed that cocaine hydrochloride injection excited high blood volume in brain. This result shows PAI can be used to monitor drug abuse-induced brain activation.

Paper Details

Date Published: 22 February 2011
PDF: 8 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993W (22 February 2011); doi: 10.1117/12.875670
Show Author Affiliations
Janggun Jo, The Univ. of Kansas (United States)
Xinmai Yang, The Univ. of Kansas (United States)

Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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