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Proceedings Paper

Initial experiences in the photoacoustic detection of melanoma metastases in resected lymph nodes
Author(s): D. Grootendorst; J. Jose; P. Van der Jagt; W. Van der Weg; K. Nagel; M. Wouters; H. Van Boven; T. G. Van Leeuwen; W. Steenbergen; T. Ruers; S. Manohar
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Paper Abstract

Accurate lymph node analysis is essential to determine the prognosis and treatment of patients suffering from melanoma. The initial results of a tomographic photoacoustic modality to detect melanoma metastases in resected lymph nodes are presented based on phantom models and a human lymph node. The results show melanoma metastases detection is feasible and the setup is capable of distinguishing absorbing structures down to 1 mm. In addition, the use of longer laser wavelengths could result in an image containing a higher contrast ratio. Future research shall be focused on using the melanin characteristics to improve contrast and detection possibilities.

Paper Details

Date Published: 22 February 2011
PDF: 7 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993J (22 February 2011); doi: 10.1117/12.875456
Show Author Affiliations
D. Grootendorst, Univ. of Twente (Netherlands)
J. Jose, Univ. of Twente (Netherlands)
P. Van der Jagt, Univ. of Twente (Netherlands)
W. Van der Weg, Univ. of Twente (Netherlands)
K. Nagel, Univ. of Twente (Netherlands)
M. Wouters, The Netherlands Cancer Institute (Netherlands)
H. Van Boven, The Netherlands Cancer Institute (Netherlands)
T. G. Van Leeuwen, Univ. of Twente (Netherlands)
Univ. of Amsterdam (Netherlands)
W. Steenbergen, Univ. of Twente (Netherlands)
T. Ruers, The Netherlands Cancer Institute (Netherlands)
Univ. of Twente (Netherlands)
S. Manohar, Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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