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Proceedings Paper

Image contrast in fluorescence and magnetic resonance images for glioblastoma detection
Author(s): Kimberley S. Samkoe; Summer L. Gibbs-Strauss; Harold H. Yang; S. Khan Hekmatyar; P. Jack Hoopes; Julia A. O'Hara; Risto A. Kauppinen; Brian W. Pogue
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Paper Abstract

A diffusely infiltrative human glioma cell line (U251-GFP) has been developed and used as a model for the tumor growth outside of MR image detectable tumor boundary. The aminolevulinic acid-protoporphyrin IX (ALA-PpIX) fluorescence system has shown great strides for fluorescence guided surgical resection, but often fluorescence is observed outside of the MR image detectable tumor margin. Here we compare the use of ALA-PpIX fluorescence with that of standard gadolinium enhanced MR imaging as well as T2 and diffusion imaging to determine whether there is a correlation between fluorescence and MR imaging. We found that PpIX fluorescence, T1WCD and Absolute T2 images have the highest contrast difference from controls and are likely candidates for highly infiltrative tumor detection.

Paper Details

Date Published: 10 February 2011
PDF: 5 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920O (10 February 2011); doi: 10.1117/12.875425
Show Author Affiliations
Kimberley S. Samkoe, Dartmouth College (United States)
Summer L. Gibbs-Strauss, Dartmouth College (United States)
Harold H. Yang, Dartmouth College (United States)
S. Khan Hekmatyar, Dartmouth Medical School (United States)
P. Jack Hoopes, Dartmouth College (United States)
Dartmouth Medical School (United States)
Julia A. O'Hara, Dartmouth College (United States)
Dartmouth Medical School (United States)
Risto A. Kauppinen, Dartmouth Medical School (United States)
Brian W. Pogue, Dartmouth College (United States)
Dartmouth Medical School (United States)

Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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