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Proceedings Paper

Differentiating human cervical dysplastic and normal tissue through wavelet domain characterization of intrinsic fluorescence
Author(s): Rajatesh Gudibande; Meghdoot Mozumder; Rajbeer Singh; Prasanta K. Panigrahi; Sharad Gupta; Asima Pradhan
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Paper Abstract

Wavelet Transform based multi-resolution analysis has been used to characterize the intrinsic fluorescence of both dysplastic and normal human cervical tissues. The fluorescence spectra corresponding to 325nm and 370nm excitation from cervical dysplastic tissues of 48 patients from diverse age groups are studied in detail using Morlet wavelet. The wavelet modulus maxima lines for 325nm excitation indicated a distinct shift for dysplastic tissues towards the lower wavelengths with respect to normal ones. For 370nm excitation however, the shift for dysplastic tissues were towards the higher wavelengths. Sensitivities of 72% and 81% for spectral shifts of 325 and 370nm excitations were observed in the wavelength band of 425-500nm of the intensity spectra.

Paper Details

Date Published: 22 February 2011
PDF: 6 pages
Proc. SPIE 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 790220 (22 February 2011); doi: 10.1117/12.875246
Show Author Affiliations
Rajatesh Gudibande, GMR Institute of Technology (India)
Meghdoot Mozumder, Indian Institute of Technology Kanpur (India)
Rajbeer Singh, Indian Institute of Technology Kanpur (India)
Prasanta K. Panigrahi, Indian Institute of Science Education and Research Kolkata (India)
Sharad Gupta, Univ. of California, Riverside (United States)
Asima Pradhan, Indian Institute of Technology Kanpur (India)

Published in SPIE Proceedings Vol. 7902:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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