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Proceedings Paper

Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer
Author(s): Alex Thompson; Hugh Manning; Mikkel Brydegaard; Sergio Coda; Gordon Kennedy; Rakesh Patalay; Ulrika Waitong-Braemming; Pieter De Beule; Mark Neil; Stefan Andersson-Engels; Yoshifumi Itoh; Niels Bendsøe; Christopher Dunsby; Katarina Svanberg; Paul M. French
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Paper Abstract

We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.

Paper Details

Date Published: 16 February 2011
PDF: 10 pages
Proc. SPIE 7895, Optical Biopsy IX, 78950G (16 February 2011); doi: 10.1117/12.875120
Show Author Affiliations
Alex Thompson, Imperial College London (United Kingdom)
Hugh Manning, Imperial College London (United Kingdom)
Mikkel Brydegaard, Lund Univ. (Sweden)
Sergio Coda, Imperial College London (United Kingdom)
Gordon Kennedy, Imperial College London (United Kingdom)
Rakesh Patalay, Imperial College London (United Kingdom)
Ulrika Waitong-Braemming, Lund Univ. Hospital (Sweden)
Pieter De Beule, Imperial College London (United Kingdom)
Mark Neil, Imperial College London (United Kingdom)
Stefan Andersson-Engels, Lund Univ. (Sweden)
Yoshifumi Itoh, Imperial College London (United Kingdom)
Niels Bendsøe, Lund Univ. Hospital (Sweden)
Christopher Dunsby, Imperial College London (United Kingdom)
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Paul M. French, Imperial College London (United Kingdom)

Published in SPIE Proceedings Vol. 7895:
Optical Biopsy IX
Robert R. Alfano, Editor(s)

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