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Proceedings Paper

In utero imaging of mouse embryonic development with optical coherence tomography
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Paper Abstract

Studying progression of congenital diseases in animal models can greatly benefit from live embryonic imaging Mouse have long served as a model of mammalian embryonic developmental processes, however, due to intra-uterine nature of mammalian development live imaging is challenging. In this report we present results on live mouse embryonic imaging in utero with Optical Coherence Tomography. Embryos from 12.5 through 17.5 days post-coitus (dpc) were studied through the uterine wall. In longitudinal studies, same embryos were imaged at developmental stages 13.5, 15.5 and 17.5 dpc. This study suggests that OCT can serve as a powerful tool for live mouse embryo imaging. Potentially this technique can contribute to our understanding developmental abnormalities associated with mutations, toxic drugs.

Paper Details

Date Published: 11 February 2011
PDF: 5 pages
Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78890A (11 February 2011); doi: 10.1117/12.874963
Show Author Affiliations
Saba H. Syed, Univ. of Houston (United States)
Mary E. Dickinson, Baylor College of Medicine (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)
Saratov State Univ. (Russian Federation)
Irina V. Larina, Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 7889:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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