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Proceedings Paper

Noninvasive quantification of metabolic rate of oxygen (MRO2) by photoacoustic microscopy
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Paper Abstract

Many diseases, normal decay and physiological functions are closely related to alterations in the metabolic rate of oxygen (MRO2). In this study, we demonstrate that all the parameters for MRO2 quantification can be simultaneously obtained by optical-resolution photoacoustic microscopy (OR-PAM). MRO2 of the mouse ear under normothermia (31 °C skin temperature) and controlled systematic hyperthermia (42 °C skin temperature) was studied. As a result of hyperthermia, the MRO2 increased by 34.1%. The tumor hypermetabolism was also demonstrated by longitudinally monitoring a melanoma growing on a mouse ear. The results show that OR-PAM, as a single noninvasive imaging modality, is well suited for quantitative MRO2 measurement in microenvironments.

Paper Details

Date Published: 17 February 2011
PDF: 6 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990N (17 February 2011);
Show Author Affiliations
Junjie Yao, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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