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Proceedings Paper

A MEMS ultrasonic sensor design for early detection of ovarian cancer
Author(s): Onursal Onen; Patricia Kruk; Rasim Guldiken
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Paper Abstract

In this study, we investigate a simple, disposable, low-cost, ultrasensitive, and fully-integrated biosensor chip for early ovarian cancer detection. The proposed sensor quantifies urinary anti-apoptotic protein Bcl-2 level that is elevated at various stages of ovarian cancer. Our approach utilizes MEMS ultrasonic transducers that have been demonstrated to be advantageous when compared to piezoelectric transducers. Piezoelectric transducers are expensive, bioincompatible (contain lead), and cannot be integrated in a fully-packaged chip. More importantly, these transducers lack the sensitivity required for early ovarian cancer detection, expensive, not biocompatible (contains Lead) and cannot be integrated for a fully-packaged chip. Our experimentally verified simulations indicate 0.15 pg/ml mass sensitivity with our sensor.

Paper Details

Date Published: 14 February 2011
PDF: 7 pages
Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290X (14 February 2011); doi: 10.1117/12.874718
Show Author Affiliations
Onursal Onen, Univ. of South Florida (United States)
Patricia Kruk, Univ. of South Florida Health (United States)
Rasim Guldiken, Univ. of South Florida (United States)

Published in SPIE Proceedings Vol. 7929:
Microfluidics, BioMEMS, and Medical Microsystems IX
Holger Becker; Bonnie L. Gray, Editor(s)

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