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Proceedings Paper

Deep illumination angular domain spectroscopic imaging: tissue-mimicking phantom study
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Paper Abstract

The angular filter array (AFA) is a silicon micro-machined optical collimator, which only accepts photons propagating within a narrow solid angle. It can be used to select photons exiting an imaging sample along a specific direction. This paper describes a novel Angular Domain Spectroscopic Imaging (ADSI) technique that utilizes deep illumination from the front surface of the sample and a camera with an AFA to image features embedded inside a turbid medium. This approach permitted spectroscopic imaging of turbid samples too thick to be imaged in a trans-illumination setup. The tissue-mimicking test phantom contained three groups of Indocyanine Green doped inclusions at depths from 1 to 3 mm embedded within an IntralipidTM/agarose gel. The sample was scanned across the AFA and the intensity of the back scattered light along the direction normal to the surface was acquired as a function of location and wavelength. The resultant spectral images were captured and analyzed. The experiments demonstrated that ADSI could detect subsurface features that differed in wavelength-dependent absorption and/or scattering properties from the surrounding medium with the deep illumination configuration. Deep illumination ADSI may be useful as a non-invasive tissue imaging tool.

Paper Details

Date Published: 17 February 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789634 (17 February 2011); doi: 10.1117/12.874634
Show Author Affiliations
Yan Zhang, Simon Fraser Univ. (Canada)
Fartash Vasefi, Simon Fraser Univ. (Canada)
Lawson Research Institute (Canada)
Univ. of Western Ontario (Canada)
Eldon Ng, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Astrid Chamson-Reig, Lawson Health Research Institute (Canada)
Bozena Kaminska, Simon Fraser Univ. (Canada)
Jeffrey J. L. Carson, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)

Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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