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Proceedings Paper

Detection of rheumatoid arthritis using infrared imaging
Author(s): Monique Frize; Cynthia Adéa; Pierre Payeur; Gina Di Primio M.D.; Jacob Karsh; Abiola Ogungbemile
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Paper Abstract

Rheumatoid arthritis (RA) is an inflammatory disease causing pain, swelling, stiffness, and loss of function in joints; it is difficult to diagnose in early stages. An early diagnosis and treatment can delay the onset of severe disability. Infrared (IR) imaging offers a potential approach to detect changes in degree of inflammation. In 18 normal subjects and 13 patients diagnosed with Rheumatoid Arthritis (RA), thermal images were collected from joints of hands, wrists, palms, and knees. Regions of interest (ROIs) were manually selected from all subjects and all parts imaged. For each subject, values were calculated from the temperature measurements: Mode/Max, Median/Max, Min/Max, Variance, Max-Min, (Mode-Mean), and Mean/Min. The data sets did not have a normal distribution, therefore non parametric tests (Kruskal-Wallis and Ranksum) were applied to assess if the data from the control group and the patient group were significantly different. Results indicate that: (i) thermal images can be detected on patients with the disease; (ii) the best joints to image are the metacarpophalangeal joints of the 2nd and 3rd fingers and the knees; the difference between the two groups was significant at the 0.05 level; (iii) the best calculations to differentiate between normal subjects and patients with RA are the Mode/Max, Variance, and Max-Min. We concluded that it is possible to reliably detect RA in patients using IR imaging. Future work will include a prospective study of normal subjects and patients that will compare IR results with Magnetic Resonance (MR) analysis.

Paper Details

Date Published: 10 March 2011
PDF: 11 pages
Proc. SPIE 7962, Medical Imaging 2011: Image Processing, 79620M (10 March 2011); doi: 10.1117/12.874552
Show Author Affiliations
Monique Frize, Carleton Univ. (Canada)
Univ. of Ottawa (Canada)
Cynthia Adéa, Carleton Univ. (Canada)
Pierre Payeur, Univ. of Ottawa (Canada)
Gina Di Primio M.D., Univ. of Ottawa (Canada)
The Ottawa Hospital (Canada)
Jacob Karsh, The Ottawa Hospital (Canada)
Abiola Ogungbemile, Carleton Univ. (Canada)

Published in SPIE Proceedings Vol. 7962:
Medical Imaging 2011: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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