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Proceedings Paper

Multiphoton imaging and quantification of tissue glycation
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Paper Abstract

In this work, we applied multi-photon microscopy to image and characterize the extent of tissue glycation. Specifically, features of multi-photon autofluorescence (MPAF) and second harmonic generation (SHG) images were presented. Our study shows that multiphoton imaging is capable of providing qualitative and quantitative information of the extent of tissue glycation in ribose treated samples including bovine sclera and vessel and that this approach may be useful for clinical evaluation of advanced glycation endproducts (AGEs) formation.

Paper Details

Date Published: 16 February 2011
PDF: 5 pages
Proc. SPIE 7895, Optical Biopsy IX, 789509 (16 February 2011); doi: 10.1117/12.874536
Show Author Affiliations
Ara A. Ghazaryan, National Taiwan Univ. (Taiwan)
Jo-Ya Tseng, National Taiwan Univ. (Taiwan)
Wen Lo, National Taiwan Univ. (Taiwan)
National Cheng Kung Univ. (Taiwan)
Yang-Fang Chen, National Taiwan Univ. (Taiwan)
Vladimir Hovhannisyan, National Taiwan Univ. (Taiwan)
Shean-Jen Chen, National Cheng Kung Univ. (Taiwan)
Hsin-Yuan Tan, National Taiwan Univ. (Taiwan)
Chang Gung Memorial Hospital (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 7895:
Optical Biopsy IX
Robert R. Alfano, Editor(s)

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