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Proceedings Paper

Size- and structure-dependent toxicity of silica particulates
Author(s): Sanshiro Hanada; Kenichi Miyaoi; Akiyoshi Hoshino; Susumu Inasawa; Yukio Yamaguchi; Kenji Yamamoto M.D.
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Paper Abstract

Nano- and micro-particulates firmly attach with the surface of various biological systems. In some chronic pulmonary disease such as asbestosis and silicosis, causative particulates will induce chronic inflammatory disorder, followed by poor prognosis diseases. However, nano- and micro-scale specific toxicity of silica particulates is not well examined enough to recognize the risk of nano- and micro-particulates from the clinical aspect. To clarify the effect of the size and structure of silica particulates on the cellular damage and the biological response, we assessed the cytotoxicity of the various kinds of silica particles including amorphous and crystalline silica, in mouse alveolar macrophage culture, focusing on the fibrotic and inflammatory response. Our study showed that the cytotoxicity, which depends on the particle size and surface area, is correlated with their inflammatory response. By contrast, production of TGF-β, which is one of the fibrotic agents in lung, by addition of crystal silica was much higher than that of amorphous silica. We conclude that fibrosis and inflammation are induced at different phases and that the size- and structure-differences of silica particulates affect the both biological responses, caused by surface activity, radical species, and so on.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79090A (11 February 2011); doi: 10.1117/12.874477
Show Author Affiliations
Sanshiro Hanada, National Ctr. for Global Health and Medicine (Japan)
Kenichi Miyaoi, Univ. Tokyo (Japan)
Akiyoshi Hoshino, National Ctr. for Global Health and Medicine (Japan)
Susumu Inasawa, The Univ. of Tokyo (Japan)
Yukio Yamaguchi, The Univ. of Tokyo (Japan)
Kenji Yamamoto M.D., National Ctr. for Global Health and Medicine (Japan)

Published in SPIE Proceedings Vol. 7909:
Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI
Wolfgang J. Parak; Kenji Yamamoto M.D.; Marek Osinski, Editor(s)

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