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Proceedings Paper

Potentialities of a new bimodal Xray/fluorescence tomograph within a cyindrical geometry for pre-clinical studies
Author(s): Anne Koenig; Anne Planat-Chrétien; Jean-Guillaume Coutard; Lionel Hervé; Marco Brambilla; Véronique Josserand; Jean-Luc Coll; Jean-Marc Dinten
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Paper Abstract

An instrument dedicated to the co-registration of optical and X-ray measurements is presented: specific acquisition protocol and reconstruction software have been developed for carrying out fluorescence diffuse optical tomography in a cylindrical geometry consistent with XCT. Actual animal geometry provided by the X-ray tomography is used to give animal boundaries to the diffuse optical tomography reconstruction algorithm. To evaluate performances of this new optical imaging system, experiments have been conducted on phantoms, mice with fluorescent capillaries, and finally on mice bearing tumors. The fluorescence reconstructions are shown to be geometrically consistent with X-ray ones. We determined that the sensibility limit of the system to detect fluorescence signal over intrinsic ones is 2 pmol for lungs area and 5 pmol for the abdomen area.

Paper Details

Date Published: 10 February 2011
PDF: 10 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920J (10 February 2011); doi: 10.1117/12.874453
Show Author Affiliations
Anne Koenig, CEA, LETI-MINATEC (France)
Anne Planat-Chrétien, CEA, LETI-MINATEC (France)
Jean-Guillaume Coutard, CEA, LETI-MINATEC (France)
Lionel Hervé, CEA, LETI-MINATEC (France)
Marco Brambilla, CEA, LETI-MINATEC (France)
Véronique Josserand, Institut Albert Bonniot (France)
Jean-Luc Coll, Institut Albert Bonniot (France)
Jean-Marc Dinten, CEA, LETI-MINATEC (France)

Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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