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Proceedings Paper

Optical-resolution photoacoustic microscopy of ischemic stroke
Author(s): Song Hu; Ernie Gonzales; Brian Soetikno; Enhao Gong; Ping Yan; Konstantin Maslov; Jin-Moo Lee; Lihong V. Wang
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Paper Abstract

A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO2) values of feeder arteries and draining veins within the stroke core region dropped ~10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO2 increased above the baseline value by ~7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction.

Paper Details

Date Published: 10 February 2011
PDF: 5 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789906 (10 February 2011); doi: 10.1117/12.874366
Show Author Affiliations
Song Hu, Washington Univ. in St. Louis (United States)
Ernie Gonzales, Washington Univ. School of Medicine (United States)
Brian Soetikno, Washington Univ. in St. Louis (United States)
Enhao Gong, Washington Univ. in St. Louis (United States)
Ping Yan, Washington Univ. School of Medicine (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Jin-Moo Lee, Washington Univ. School of Medicine (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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