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Proceedings Paper

Trimodal spectra for high discrimination of benign and malignant prostate tissue
Author(s): Mohamad Al Salhi; Vadivel Masilamani; Vijmasi Trinka; Danny Rabah; Mohammed R. Al Turki
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Paper Abstract

High false positives and over diagnosis is a major problem with management of prostate cancer. A non-invasive or a minimally invasive technique to accurately distinguish malignant prostate cancers from benign tumors will be extremely helpful to overcome this problem. In this paper, we had used three different fluorescence spectroscopy techniques viz., Fluorescence Emission Spectrum (FES), Stokes' Shift Spectrum (SSS) and Reflectance Spectrum (RS) to discriminate benign prostate tumor tissues (N=12) and malignant prostate cancer tissues (N=8). These fluorescence techniques were used to determine the relative concentration of naturally occurring biomolecules such as tryptophan, elastin, NADH and flavin which are found to be out of proportion in cancer tissues. Our studies show that combining all three techniques, benign and malignant prostate tissues could be classified with accuracy greater than 90%. This preliminary report is based on in vitro spectroscopy analysis. However, by employing fluorescence endoscopy techniques, this can be extended to in vivo analysis as well. This technique has the potential to identify malignant prostate tissues without surgery.

Paper Details

Date Published: 1 March 2011
PDF: 10 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78961C (1 March 2011); doi: 10.1117/12.874012
Show Author Affiliations
Mohamad Al Salhi, King Saud Univ. (Saudi Arabia)
Vadivel Masilamani, King Saud Univ. (Saudi Arabia)
Vijmasi Trinka, Thendrel Inc. (United States)
Danny Rabah, King Saud Univ. (Saudi Arabia)
Mohammed R. Al Turki, King Saud Hospital Complex (Saudi Arabia)

Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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