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Proceedings Paper

A potential individual cell malignancy indicator: focal length
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Paper Abstract

The label-free technique of optofluidic intracavity spectroscopy (OFIS) utilizes the optical transmission spectrum of a cell in a microfluidic Fabry-Pérot (F-P) cavity to distinguish cells from cancerous cell lines and baseline normal blood cells. The classification between canine hemangiosarcoma (HSA) cancer cells and monocytes in canine normal peripheral blood mononuclear cells (PBMCs) had been demonstrated with 95% sensitivity and 98% specificity. Now with a new optical model that treats the cell settled at the bottom of the cavity as a thin lens, the focal length of cells was extracted and used as an individual cell malignancy indicator.

Paper Details

Date Published: 21 February 2011
PDF: 8 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 789002 (21 February 2011); doi: 10.1117/12.873972
Show Author Affiliations
Weina Wang, Colorado State Univ. (United States)
Kevin L. Lear, Colorado State Univ. (United States)

Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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