Share Email Print

Proceedings Paper

Non-invasive optical modulation of local vascular permeability
Author(s): Myunghwan Choi; Chulhee Choi M.D.
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

For a systemically administered drug to act, it first needs to cross the vascular wall. This step represents a bottleneck for drug development, especially in the brain or retina, where tight junctions between endothelial cells form physiological barriers. Here, we demonstrate that femtosecond pulsed laser irradiation focused on the blood vessel wall induces transient permeabilization of plasma. Nonlinear absorption of the pulsed laser enabled the noninvasive modulation of vascular permeability with high spatial selectivity in three dimensions. By combining this method with systemic injection, we could locally deliver molecular probes in various tissues, such as brain cortex, meninges, ear, striated muscle, and bone. We suggest this method as a novel delivery tool for molecular probes or drugs.

Paper Details

Date Published: 17 February 2011
PDF: 5 pages
Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78970A (17 February 2011); doi: 10.1117/12.873832
Show Author Affiliations
Myunghwan Choi, KAIST (Korea, Republic of)
Chulhee Choi M.D., KAIST (Korea, Republic of)

Published in SPIE Proceedings Vol. 7897:
Optical Interactions with Tissue and Cells XXII
E. Duco Jansen; Robert J. Thomas, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?