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Proceedings Paper

A compact, cost-effective diffuse reflectance spectroscopic imaging system for quantitative tissue absorption and scattering
Author(s): Justin Y. Lo; Bing Yu; Thomas F. Kuech; Nirmala Ramanujam
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Paper Abstract

There is clinical utility for a wide-field, spectroscopic imaging device for quantitative tissue absorption and scattering in a number of applications. We present the design of a compact, cost-effective spectroscopic imaging system, which consists of a broadband source with bandpass filters and a light guide for illumination and an inexpensive array of silicon photodiodes for detection. A single-pixel version of the system was tested in liquid phantoms simulating a wide range of human breast tissue and optical properties can be extracted with absorption and reduced scattering errors of 12.6% and 4.7%, respectively. We show proof-of-concept for performing fast, wide-field spectroscopic imaging with a simple design. The design also allows for scaling and expansion into higher pixel number and density in future iterations of custom device design, which includes in-house photodiode array fabrication processes and integration of on-board current amplifier circuits.

Paper Details

Date Published: 21 February 2011
PDF: 6 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900B (21 February 2011); doi: 10.1117/12.873617
Show Author Affiliations
Justin Y. Lo, Duke Univ. (United States)
Bing Yu, Duke Univ. (United States)
Thomas F. Kuech, Univ. of Wisconsin, Madison (United States)
Nirmala Ramanujam, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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