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Proceedings Paper

Small-animal whole-body imaging using a photoacoustic full ring array system
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Paper Abstract

In this report, we present a novel 3D photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The PACT system, based on a 512-element full-ring transducer array, received photoacoustic signals primarily from a 2-mm-thick slice. The light was generated by a pulse laser, and can either illuminate from the top or be reshaped to illuminate the sample from the side, using a conical lens and an optical condenser. The PACT system was capable of acquiring an in-plane image in 1.6 s; by scanning the sample in the elevational direction, a 3D tomographic image could be constructed. We tested the system by imaging a cylindrical phantom made of human hairs immersed in a scattering medium. The reconstructed image achieved an in-plane resolution of 0.1 mm and an elevational resolution of 1 mm. After deconvolution in the elevational direction, the 3D image was found to match well with the phantom. The system was also used to image a baby mouse in situ; the spinal cord and ribs can be seen easily in the reconstructed image. Our results demonstrate that the PACT system has the potential to be used for fast small-animal whole-body tomographic imaging.

Paper Details

Date Published: 17 February 2011
PDF: 5 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789911 (17 February 2011); doi: 10.1117/12.873401
Show Author Affiliations
Jun Xia, Washington Univ. in St Louis (United States)
Zijian Guo, Washington Univ. in St Louis (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)
Lihong V. Wang, Washington Univ. in St Louis (United States)

Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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