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Proceedings Paper

Brain lesion induced by 1319nm laser radiation
Author(s): Zaifu Yang; Hongxia Chen; Jiarui Wang; Peng Chen; Ping Ma; Huanwen Qian
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Paper Abstract

The laser-tissue interaction has not been well defined at the 1319 nm wavelength for brain exposure. The goal of this research effort was to identify the behavioral and histological changes of brain lesion induced by 1319 nm laser. The experiment was performed on China Kunming mice. Unilateral brain lesions were created with a continuous-wave Nd:YAG laser (1319nm). The brain lesions were identified through behavioral observation and histological haematoxylin and eosin (H&E) staining method. The behavior change was observed for a radiant exposure range of 97~773 J/cm2. The histology of the recovery process was identified for radiant exposure of 580 J/cm2. Subjects were sacrificed 1 hour, 1 week, 2 weeks, 3 months, 7 months and 13 months after laser irradiation. Results showed that after laser exposure, behavioral deficits, including kyphosis, tail entasia, or whole body paralysis could be noted right after the animals recovered from anesthesia while gradually disappeared within several days and never recurred again. Histologically, the laser lesion showed a typical architecture dependent on the interval following laser treatment. The central zone of coagulation necrosis is not apparent right after exposure but becomes obvious within several days. The nerotic tissue though may persist for a long time, will finally be completely resorbed. No carbonization granules formed under our exposure condition.

Paper Details

Date Published: 8 November 2010
PDF: 7 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 784511 (8 November 2010); doi: 10.1117/12.870560
Show Author Affiliations
Zaifu Yang, Beijing Institute of Radiation Medicine (China)
Hongxia Chen, Chinese PLA General Hospital (China)
Jiarui Wang, Beijing Institute of Radiation Medicine (China)
Peng Chen, Beijing Institute of Radiation Medicine (China)
Ping Ma, Beijing Institute of Radiation Medicine (China)
Huanwen Qian, Beijing Institute of Radiation Medicine (China)

Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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