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Proceedings Paper

Determination of singlet oxygen quantum yield of HiPorfin using Singlet Oxygen Sensor Green
Author(s): Huiyun Lin; Yi Shen; Defu Chen; Lisheng Lin; Buhong Li; Shusen Xie
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Paper Abstract

Singlet oxygen (1O2) is widely considered to be the predominant cytotoxic agent for photodynamic therapy (PDT), and the 1O2 quantum yield is a key characteristic for the newly developed photosensitizers. In this study, 1O2 generation from the HiPorfin is monitored indirectly by using the fluorescence probe Singlet Oxygen Sensor Green (SOSG). The good linear relationship between the concentration of HiPorfin and the initial reaction rate of SOSG is observed, and the 1O2 quantum yield of HiPorfin is determined to be 0.124 ± 0.001, as compared to the standard reference of Rose Bengal. The results suggest that SOSG can be useful for 1O2 quantum yield determination for the potential photosensitizers in PDT.

Paper Details

Date Published: 8 November 2010
PDF: 6 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78451J (8 November 2010); doi: 10.1117/12.870108
Show Author Affiliations
Huiyun Lin, Fujian Normal Univ. (China)
Yi Shen, Fujian Normal Univ. (China)
Defu Chen, Fujian Normal Univ. (China)
Lisheng Lin, Fujian Normal Univ. (China)
Buhong Li, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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