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Proceedings Paper

A novel nasopharyngeal cancer detection based on plasma SERS combined with PCA-LDA statistical analysis
Author(s): Shangyuan Feng; Juqiang Lin; Jianji Pan; Jiesi Chen; Yongzeng Li; Yanan Wu; Haishan Zeng; Rong Chen
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Paper Abstract

In order to develop a novel and simple blood test for non-invasive nasopharyngeal cancer detection, a surface-enhanced Raman spectroscopy (SERS) method was presented for blood plasma biochemical analysis. High quality SERS spectrum from human plasma-Ag NP mixture can be obtained using a confocal Raman system. SERS measurements were performed on normal and cancer groups of plasma samples. The measured SERS spectra revealed some specific biomolecular differences in nasopharyngeal cancer plasma. Principal component analysis of the measured SERS spectra separated the spectral features of the two groups into two distinct clusters with little overlaps. Linear discriminate analysis based on the PCA generated features differentiated the nasopharyngeal cancer SERS spectra from normal SERS spectra with high sensitivity (97.7%) and specificity (100%). The results from this exploratory study illustrated great promising for developing SERS human plasma analysis into a clinical tool for non-invasive detection of nasopharyngeal cancers.

Paper Details

Date Published: 8 November 2010
PDF: 6 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78452C (8 November 2010); doi: 10.1117/12.870082
Show Author Affiliations
Shangyuan Feng, Fujian Normal Univ. (China)
Juqiang Lin, Fujian Normal Univ. (China)
Jianji Pan, Fujian Provincial Tumor Hospital (China)
Jiesi Chen, Fujian Normal Univ. (China)
Yongzeng Li, Fujian Normal Univ. (China)
Yanan Wu, Fujian Provincial Hospital (China)
Haishan Zeng, British Columbia Cancer Research Ctr. (Canada)
Rong Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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