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Proceedings Paper

Experimental demonstration of lossy recording of information into DNA
Author(s): Maria E. Tanner; Elizabeth A. Vasievich; Jonathan M. Protz
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Paper Abstract

Non-coding DNA comprises the majority of an organism's DNA and has the potential to store massive amounts of information. We hypothesize that information can be stored into non-coding DNA using a noisy mechanism comprised of thermally sensitive liposomes as sensors and measuring transport state variable information through DNA release and binding in response to stimuli. To test our hypothesis, we performed experiments that demonstrated the in situ, de novo synthesis of information-encoding DNA using natural biomaterials. Our results were compared to a lumped-parameter model designed to simulate the experiments. We found promising correlation between the DNA sequences generated by the simulations and those generated experimentally, suggesting that the in situ, de novo synthesized DNA does store recoverable information by the mechanism proposed.

Paper Details

Date Published: 5 May 2010
PDF: 6 pages
Proc. SPIE 7679, Micro- and Nanotechnology Sensors, Systems, and Applications II, 76792O (5 May 2010); doi: 10.1117/12.858775
Show Author Affiliations
Maria E. Tanner, Duke Univ. (United States)
Elizabeth A. Vasievich, The Univ. of North Carolina at Chapel Hill (United States)
Jonathan M. Protz, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7679:
Micro- and Nanotechnology Sensors, Systems, and Applications II
Thomas George; M. Saif Islam; Achyut Kumar Dutta, Editor(s)

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