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Proceedings Paper

Autofluorescence of pigmented skin lesions using a pulsed UV laser with synchronized detection: clinical results
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Paper Abstract

We report preliminary clinical results of autofluorescence imaging of malignant and benign skin lesions, using pulsed 355 nm laser excitation with synchronized detection. The novel synchronized detection system allows high signal-tonoise ratio to be achieved in the resulting autofluorescence signal, which may in turn produce high contrast images that improve diagnosis, even in the presence of ambient room light. The synchronized set-up utilizes a compact, diode pumped, pulsed UV laser at 355 nm which is coupled to a CCD camera and a liquid crystal tunable filter. The excitation and image capture is sampled at 5 kHz and the resulting autofluorescence is captured with the liquid crystal filter cycling through seven wavelengths between 420 nm and 580 nm. The clinical study targets pigmented skin lesions and evaluates the prospects of using autofluorescence as a possible means in differentiating malignant and benign skin tumors. Up to now, sixteen patients have participated in the clinical study. The autofluorescence images, averaged over the exposure time of one second, will be presented along with histopathological results. Initial survey of the images show good contrast and diagnostic results show promising agreement based on the histopathological results.

Paper Details

Date Published: 17 May 2010
PDF: 6 pages
Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151K (17 May 2010); doi: 10.1117/12.855837
Show Author Affiliations
Haynes P. H. Cheng, Technical Univ. of Denmark (Denmark)
Pontus Svenmarker, Lund Univ. (Sweden)
Haiyan Xie, Lund Univ. (Sweden)
Peter Tidemand-Lichtenberg, Technical Univ. of Denmark (Denmark)
Ole B. Jensen, Technical Univ. of Denmark (Denmark)
Niels Bendsoe, Lund Univ. Hospital (Sweden)
Katarina Svanberg M.D., Lund Univ. Hospital (Sweden)
Paul Michael Petersen, Technical Univ. of Denmark (Denmark)
Christian Pedersen, Technical Univ. of Denmark (Denmark)
Stefan Andersson-Engels, Lund Univ. (Sweden)
Peter E. Andersen, Technical Univ. of Denmark (Denmark)

Published in SPIE Proceedings Vol. 7715:
Biophotonics: Photonic Solutions for Better Health Care II
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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