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Proceedings Paper

Full-field, nonscanning, optical imaging for perfusion indication
Author(s): Nee-Yin Chou; L. W. Winchester Jr.; W. J. Naramore; M. S. Alley; A. J. Lesnick
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Paper Abstract

Laser speckle imaging (LSI) has been gaining popularity for the past few years. Like other optical imaging modalities such as optical coherence tomography (OCT), orthogonal polarization spectroscopy (OPS), and laser Doppler imaging (LDI), LSI utilizes nonionizing radiation. In LSI, blood flow velocity is obtained by analyzing, temporally or spatially, laser speckle (LS) patterns generated when an expanded laser beam illuminates the tissue. The advantages of LSI are that it is fast, does not require scanning, and provides full-field LS images to extract realtime, quantitative hemodynamic information of subtle changes in the tissue vasculature. For medical applications, LSI has been used for obtaining blood velocities in human retina, skin flaps, wounds, and cerebral and sublingual areas. When coupled with optical fibers, LSI can be used for endoscopic measurements for a variety of applications. This paper describes the application of LSI in retinal, sublingual, and skin flap measurements. Evaluation of retinal hemodynamics provides very important diagnostic information, since the human retina offers direct optical access to both the central nervous system (CNS) and afferent and efferent CNS vasculature. The performance of an LSI-based fundus imager for measuring retinal hemodynamics is presented. Sublingual microcirculation may have utility for sepsis indication, since inherent in organ injury caused by sepsis is a profound change in microvascular hemodynamics. Sublingual measurement results using an LSI scope are reported. A wound imager for imaging LS patterns of wounds and skin flaps is described, and results are presented.

Paper Details

Date Published: 12 April 2010
PDF: 12 pages
Proc. SPIE 7703, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII, 77030S (12 April 2010); doi: 10.1117/12.855071
Show Author Affiliations
Nee-Yin Chou, CW Optics, Inc. (United States)
L. W. Winchester Jr., CW Optics, Inc. (United States)
W. J. Naramore, CW Optics, Inc. (United States)
M. S. Alley, CW Optics, Inc. (United States)
A. J. Lesnick, CW Optics, Inc. (United States)

Published in SPIE Proceedings Vol. 7703:
Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII
Harold H. Szu; F. Jack Agee, Editor(s)

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