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Proceedings Paper

Coherent anti-stokes Raman scattering (RP-CARS) microscopy for sensing molecular orientations
Author(s): Wei Zheng; Zhiwei Huang
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Paper Abstract

We report coherent anti-Stokes Raman scattering (CARS) microscopy with radially polarized (RP) excitation for facilitating longitudinally oriented molecules detection. Our finite-difference time-domain (FDTD) simulation results show that the maximum near-field RP-CARS radiation from the two longitudinally orientated nanoparticles is around 1.3 times higher than that from transversely orientated nanoparticles. Our further CARS experiments show that RP-CARS radiation from molecules oriented along the longitudinal direction is approximately 3-fold stronger than that using linearly polarized CARS technique, and the lateral resolution of RP-CARS imaging can be improved by about 10% compared to the linearly polarized CARS imaging.

Paper Details

Date Published: 25 November 2009
PDF: 5 pages
Proc. SPIE 7634, Optical Sensors and Biophotonics, 76340V (25 November 2009); doi: 10.1117/12.854965
Show Author Affiliations
Wei Zheng, National Univ. of Singapore (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 7634:
Optical Sensors and Biophotonics
Xingde Li; Qingming Luo; Vasilis Ntziachristos; Yoshiaki Yasuno, Editor(s)

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