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Proceedings Paper

Aptamer-based surface plasmon fibre sensor for thrombin detection
Author(s): T. Allsop; D. Nagel; R. Neal; E. M. Davies; C. Mou; P. Bond; S. Rehman; K. Kalli; D. J. Webb; P. Calverhouse; M. Mascini; I. Bennion
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Paper Abstract

A series of surface plasmonic fibre devices were fabricated using multiple coatings deposited on a lapped section of a single mode fibre and post-fabrication UV laser irradiation processing with a phase mask, producing a surface relief grating structure. These devices showed high spectral sensitivity in the aqueous index regime ranging up to 4000 nm/RIU for wavelength and 800 dB/RIU for intensity. The devices were then coated with human thrombin binding aptamer. Several concentrations of thrombin in buffer solution were made, ranging from 1nM to 1μM. All the concentrations were detectable by the devices demonstrating that sub-nM concentrations may be monitored.

Paper Details

Date Published: 17 May 2010
PDF: 6 pages
Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151C (17 May 2010); doi: 10.1117/12.854334
Show Author Affiliations
T. Allsop, Aston Univ. (United Kingdom)
D. Nagel, Aston Univ. (United Kingdom)
R. Neal, Univ. of Plymouth (United Kingdom)
E. M. Davies, Aston Univ. (United Kingdom)
C. Mou, Aston Univ. (United Kingdom)
P. Bond, Univ. of Plymouth (United Kingdom)
S. Rehman, STR Fiber Technologies (United Kingdom)
K. Kalli, Cyprus Univ. of Technology (Cyprus)
D. J. Webb, Aston Univ. (United Kingdom)
P. Calverhouse, Univ. of Plymouth (United Kingdom)
M. Mascini, Univ. degli Studi di Firenze (Italy)
I. Bennion, Aston Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 7715:
Biophotonics: Photonic Solutions for Better Health Care II
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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