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Proceedings Paper

Near-infrared autofluorescence imaging for colonic cancer detection
Author(s): Xiaozhuo Shao; Wei Zheng; Zhiwei Huang
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Paper Abstract

We explore an NIR autofluorescence imaging technique for cancer diagnosis and detection. A set of tissue images including NIR white light images, autofluorescence (AF) images and fluorescence polarized images (FPI) (parallel-, and perpendicular- polarization) were acquired in tandem on human colonic tissues. The results show that NIR fluorescence intensity of normal tissue is significantly higher than that of cancer tissue. The perpendicular-polarization image yields the highest diagnostic accuracy 93% compared to other imaging modes. This work demonstrates that Fluorescence polarization imaging (FPI) technique has great potential for cancer diagnosis and detection in the colon.

Paper Details

Date Published: 25 November 2009
PDF: 5 pages
Proc. SPIE 7634, Optical Sensors and Biophotonics, 76340B (25 November 2009); doi: 10.1117/12.852098
Show Author Affiliations
Xiaozhuo Shao, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 7634:
Optical Sensors and Biophotonics
Xingde Li; Qingming Luo; Vasilis Ntziachristos; Yoshiaki Yasuno, Editor(s)

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