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Proceedings Paper

In vivo detection of osteoarthritis in the hand with three-dimensional photoacoustic tomography
Author(s): Yao Sun; Eric Sobel; Huabei Jiang
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Paper Abstract

This paper presents a pilot clinical study in detecting osteoarthritis (OA) in the hand using threedimensional (3-D) photoacoustic tomography (PAT). Distal interphalangeal (DIP) finger joints from OA patients and healthy volunteers were imaged with our 3-D PAT system in a spherical scanning configuration. Absorption coefficient images of the joint tissue were obtained using our finite element based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The recovered quantitative photoacoustic images revealed significant differences in the absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and healthy joints. Quantitative analysis of the joints also indicated an apparent difference in the recovered joint spacing between OA and healthy subjects, which is in agreement with the clinical observations. This study suggests that 3D PAT has the potential to become a useful tool for diagnosis of osteoarthritis.

Paper Details

Date Published: 2 March 2010
PDF: 6 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484H (2 March 2010); doi: 10.1117/12.851723
Show Author Affiliations
Yao Sun, Univ. of Florida (United States)
Eric Sobel, College of Medicine, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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