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Proceedings Paper

Cellular uptake of conjugated InP quantum dots
Author(s): Hicham Chibli; Lina Carlini; Kalonji Ntumba; Jay Nadeau
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Paper Abstract

Indium phosphide (InP) nanocrystals show similar absorbance and emission spectra to CdTe quantum dots, but unlike particles containing cadmium, may potentially be used in in vivo applications. However, the particles are more challenging to make water-soluble, show broader emission spectra than most quantum dots, and their behavior in living cells is largely unknown. In this work we solubilize InP nanocrystals with simple thiols (mercaptopropionic acid) and conjugate them to the neurotransmitter dopamine or the protein transferrin. Degree of uptake and labeling patterns of QDs alone, QD-dopamine, and QD-transferrin are compared in different cell lines and toxicity is evaluated using the sulforhodamine B (SRB) assay.

Paper Details

Date Published: 17 February 2010
PDF: 8 pages
Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 75750T (17 February 2010); doi: 10.1117/12.848942
Show Author Affiliations
Hicham Chibli, McGill Univ. (Canada)
Lina Carlini, McGill Univ. (Canada)
Kalonji Ntumba, McGill Univ. (Canada)
Jay Nadeau, McGill Univ. (Canada)

Published in SPIE Proceedings Vol. 7575:
Colloidal Quantum Dots for Biomedical Applications V
Marek Osinski; Wolfgang J. Parak; Thomas M. Jovin M.D.; Kenji Yamamoto M.D., Editor(s)

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