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Proceedings Paper

Two-layer optical model of skin for early, non-invasive detection of wound development on the diabetic foot
Author(s): Dmitry Yudovsky; Aksone Nouvong; Kevin Schomacker; Laurent Pilon
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Paper Abstract

Foot ulceration is a debilitating comorbidity of diabetes that may result in loss of mobility and amputation. Optical detection of cutaneous tissue changes due to inflammation and necrosis at the preulcer site could constitute a preventative strategy. A commercial hyperspectral oximetry system was used to measure tissue oxygenation on the feet of diabetic patients. A previously developed predictive index was used to differentiate preulcer tissue from surrounding healthy tissue with a sensitivity of 92% and specificity of 80%. To improve prediction accuracy, an optical skin model was developed treating skin as a two-layer medium and explicitly accounting for (i) melanin content and thickness of the epidermis, (ii) blood content and hemoglobin saturation of the dermis, and (iii) tissue scattering in both layers. Using this forward model, an iterative inverse method was used to determine the skin properties from hyperspectral images of preulcerative areas. The use of this information in lowering the false positive rate was discussed.

Paper Details

Date Published: 22 February 2010
PDF: 10 pages
Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 755514 (22 February 2010); doi: 10.1117/12.846078
Show Author Affiliations
Dmitry Yudovsky, Univ. of California, Los Angeles (United States)
Aksone Nouvong, Univ. of California, Los Angeles (United States)
Kevin Schomacker, Hypermed, Inc (United States)
Laurent Pilon, Univ. of California, Los Angeles (United States)

Published in SPIE Proceedings Vol. 7555:
Advanced Biomedical and Clinical Diagnostic Systems VIII
Tuan Vo-Dinh; Warren S. Grundfest M.D.; Anita Mahadevan-Jansen, Editor(s)

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