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Proceedings Paper

Clinically compatible instrumentation for accurate detection of fluorescence intensity and lifetime in turbid media
Author(s): Ching-Wei Chang; William Lloyd; Robert Wilson; Gregory D. Gillispie; Mary-Ann Mycek
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Paper Abstract

We report data collected with a specialized transient digitizer, high repetition rate microchip laser sources, and fiber optic light delivery and collection for rapid remote sensing in tissue-simulating phantoms. The instrumentation is highly suitable for eventual translation to a clinical setting owing to the speed of data acquisition and small footprint. Ranges for data acquisition time and instrument sensitivity were determined by measuring wavelength time matrices (WTMs) from tissue-simulating phantoms. Accuracy of WTM data was validated by comparison with Monte-Carlo simulations of fluorescent light propagation in turbid media.

Paper Details

Date Published: 19 February 2010
PDF: 6 pages
Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 755503 (19 February 2010); doi: 10.1117/12.845789
Show Author Affiliations
Ching-Wei Chang, Univ. of Michigan (United States)
William Lloyd, Univ. of Michigan (United States)
Robert Wilson, Univ. of Michigan (United States)
Gregory D. Gillispie, Fluorescence Innovations (United States)
Mary-Ann Mycek, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 7555:
Advanced Biomedical and Clinical Diagnostic Systems VIII
Tuan Vo-Dinh; Warren S. Grundfest M.D.; Anita Mahadevan-Jansen, Editor(s)

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