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Proceedings Paper

Quantitative analysis on PUVA-induced skin photodamages using optical coherence tomography
Author(s): Juan Zhai; Zhouyi Guo; Zhiming Liu; Honglian Xiong; Changchun Zeng; Ying Jin
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Paper Abstract

Psoralen plus ultraviolet A radiation (PUVA) therapy is a very important clinical treatment of skin diseases such as vitiligo and psoriasis, but associated with an increased risk of skin photodamages especially photoaging. Since skin biopsy alters the original skin morphology and always requires an iatrogenic trauma, optical coherence tomography (OCT) appears to be a promising technique to study skin damage in vivo. In this study, the Balb/c mice had 8-methoxypsralen (8-MOP) treatment prior to UVA radiation was used as PUVA-induced photo-damaged modal. The OCT imaging of photo-damaged group (modal) and normal group (control) in vivo was obtained of mice dorsal skin at 0, 24, 48, 72 hours after irradiation respectively. And then the results were quantitatively analyzed combined with histological information. The experimental results showed that, PUVA-induced photo-damaged skin had an increase in epidermal thickness (ET), a reduction of attenuation coefficient in OCT images signal, and an increase in brightness of the epidermis layer compared with the control group. In conclusion, noninvasive high-resolution imaging techniques such as OCT may be a promising tool for photobiological studies aimed at assessing photo-damage and repair processes in vivo. It can be used to quantitative analysis of changes in photo-damaged skin, such as the ET and collagen in dermis, provides a theoretical basis for treatment and prevention of skin photodamages.

Paper Details

Date Published: 28 October 2009
PDF: 8 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75191C (28 October 2009); doi: 10.1117/12.843634
Show Author Affiliations
Juan Zhai, South China Normal Univ. (China)
Zhouyi Guo, South China Normal Univ. (China)
Zhiming Liu, South China Normal Univ. (China)
Honglian Xiong, South China Normal Univ. (China)
Changchun Zeng, South China Normal Univ. (China)
Ying Jin, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Pengcheng Li; Ling Fu, Editor(s)

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