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Proceedings Paper

Flicker stimulated retinal perfusion changes assessed with high-speed Doppler tomography
Author(s): Tilman Schmoll; Amardeep S. G. Singh; Karine Frily; Cedric Blatter; Martin Villiger; Christoph Pache; Theo Lasser; R. A. Leitgeb
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Paper Abstract

We developed a high speed Doppler tomography system together with flow extraction algorithms that provide a flexible tool to assess retinal perfusion. The aim of the present study is to stimulate perfusion by flickering with light of adjustable color and to measure changes depending on light frequency and flicker location. We observed relative changes in arterial flow velocity during flicker stimulation up to 50%. We found in arteries close to the optic nerve head the highest flicker response at a frequency of 8Hz. We believe that a multimodal functional imaging concept is of high value for an accurate and early diagnosis and understanding of retinal pathologies and pathogenesis.

Paper Details

Date Published: 2 March 2010
PDF: 4 pages
Proc. SPIE 7550, Ophthalmic Technologies XX, 75500F (2 March 2010); doi: 10.1117/12.842922
Show Author Affiliations
Tilman Schmoll, Medizinische Univ. Wien (Austria)
Amardeep S. G. Singh, Medizinische Univ. Wien (Austria)
Karine Frily, Medizinische Univ. Wien (Austria)
Cedric Blatter, Medizinische Univ. Wien (Austria)
Martin Villiger, Lab. d'Optique Biomedicale, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Christoph Pache, Lab. d'Optique Biomedicale, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Theo Lasser, Lab. d'Optique Biomedicale, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
R. A. Leitgeb, Medizinische Univ. Wien (Austria)

Published in SPIE Proceedings Vol. 7550:
Ophthalmic Technologies XX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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