
Proceedings Paper
Micro-tattoo guided OCT imaging of site specific inflammationFormat | Member Price | Non-Member Price |
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Paper Abstract
Epithelial biologists studying human skin diseases such as cancer formation and psoriasis commonly utilize mouse
models to characterize the interplay among cells and intracellular signal transduction pathways that result in
programmed changes in gene expression and cellular behaviors. The information obtained from animal models is
useful only when phenotypic presentations of disease recapitulate those observed in humans. Excision of tissues
followed by histochemical analysis is currently the primary means of establishing the morphological presentation.
Non invasive imaging of animal models provides an alternate means to characterize tissue morphology associated
with the disease of interest in vivo. While useful, the ability to perform in vivo imaging at different time points
in the same tissue location has been a challenge. This information is key to understanding site specific changes
as the imaged tissue can now be extracted and analyzed for mRNA expression. We present a method employing
a micro-tattoo to guide optical coherence tomography (OCT) imaging of ultraviolet induced inflammation over
time in the same tissue locations.
Paper Details
Date Published: 26 February 2010
PDF: 4 pages
Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730S (26 February 2010); doi: 10.1117/12.842570
Published in SPIE Proceedings Vol. 7573:
Biomedical Applications of Light Scattering IV
Adam P. Wax; Vadim Backman, Editor(s)
PDF: 4 pages
Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730S (26 February 2010); doi: 10.1117/12.842570
Show Author Affiliations
Kevin G. Phillips, Oregon Health & Science Univ. (United States)
Niloy Choudhury, Oregon Health & Science Univ. (United States)
Ravikant V. Samatham, Oregon Health & Science Univ. (United States)
Niloy Choudhury, Oregon Health & Science Univ. (United States)
Ravikant V. Samatham, Oregon Health & Science Univ. (United States)
Harvinder Singh, Texas Tech Univ. (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Published in SPIE Proceedings Vol. 7573:
Biomedical Applications of Light Scattering IV
Adam P. Wax; Vadim Backman, Editor(s)
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