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Proceedings Paper

Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients: results of a prospective study
Author(s): Gurjit S. Mandair; Francis W. L. Esmonde-White; Mohammed P. Akhter; Aaron M. Swift; Jaclynn Kreider; Steven A. Goldstein; Robert R. Recker; Michael D. Morris
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Paper Abstract

As part of our ongoing assessment of bone tissue composition and structure, we report the first experimental protocols of a prospective study to investigate the potential of using Raman spectroscopy to diagnose and predict skeletal fragility in postmenopausal osteoporosis patients. This multi-center study will assess several potential spectroscopic and X-ray based diagnostic techniques. One hundred and twenty participants will be enrolled in this five year study and the investigators will be blinded to information concerning patient history and status. Iliac crest bone biopsy specimens are provided with no identifying information except a patient study number. Our team will use micro-computed tomography (micro-CT) to identify regions of interest in both cortical and cancellous bone from specimens delivered to us. Raman mapping will be performed using a line-focused 785 nm laser in order to obtain local and averaged values on several spectroscopic metrics of bone quality. These metrics include carbonate/phosphate and phosphate/matrix ratios. Results from an initial set of biopsies will be presented. Protocols for obtaining measurements are discussed, with emphasis on the challenges presented by the use of fixed and polymer embedded specimens. These protocols are illustrated will data from a biopsy specimen.

Paper Details

Date Published: 2 March 2010
PDF: 9 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 754846 (2 March 2010); doi: 10.1117/12.842515
Show Author Affiliations
Gurjit S. Mandair, Univ. of Michigan (United States)
Francis W. L. Esmonde-White, Univ. of Michigan (United States)
Mohammed P. Akhter, Univ. of Michigan (United States)
Aaron M. Swift, Creighton Univ. (United States)
Jaclynn Kreider, Creighton Univ. (United States)
Steven A. Goldstein, Creighton Univ. (United States)
Robert R. Recker, Univ. of Michigan (United States)
Michael D. Morris, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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