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Proceedings Paper

Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: two case reports
Author(s): Margaret A. Naeser; Anita Saltmarche; Maxine H. Krengel; Michael R. Hamblin; Jeffrey A. Knight
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Paper Abstract

Two chronic, traumatic brain injury (TBI) cases are presented, where cognitive function improved following treatment with transcranial light emitting diodes (LEDs). At age 59, P1 had closed-head injury from a motor vehicle accident (MVA) without loss of consciousness and normal MRI, but unable to return to work as development specialist in internet marketing, due to cognitive dysfunction. At 7 years post-MVA, she began transcranial LED treatments with cluster heads (2.1" diameter with 61 diodes each - 9x633nm, 52x870nm; 12-15mW per diode; total power, 500mW; 22.2 mW/cm2) on bilateral frontal, temporal, parietal, occipital and midline sagittal areas (13.3 J/cm2 at scalp, estimated 0.4 J/cm2 to brain cortex per area). Prior to transcranial LED, focused time on computer was 20 minutes. After 2 months of weekly, transcranial LED treatments, increased to 3 hours on computer. Performs nightly home treatments (now, 5 years, age 72); if stops treating >2 weeks, regresses. P2 (age 52F) had history of closed-head injuries related to sports/military training and recent fall. MRI shows fronto-parietal cortical atrophy. Pre-LED, was not able to work for 6 months and scored below average on attention, memory and executive function. Performed nightly transcranial LED treatments at home (9 months) with similar LED device, on frontal and parietal areas. After 4 months of LED treatments, returned to work as executive consultant, international technology consulting firm. Neuropsychological testing (post- 9 months of transcranial LED) showed significant improvement in memory and executive functioning (range, +1 to +2 SD improvement). Case 2 reported reduction in PTSD symptoms.

Paper Details

Date Published: 25 February 2010
PDF: 12 pages
Proc. SPIE 7552, Mechanisms for Low-Light Therapy V, 75520L (25 February 2010); doi: 10.1117/12.842510
Show Author Affiliations
Margaret A. Naeser, VA Boston Healthcare System (United States)
Boston Univ. School of Medicine (United States)
Anita Saltmarche, MedX Health Inc. (Canada)
Maxine H. Krengel, VA Boston Healthcare System (United States)
Boston Univ. School of Medicine (United States)
Michael R. Hamblin, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Harvard-MIT Div. of Health Sciences and Technology (United States)
Jeffrey A. Knight, VA Boston Healthcare System (United States)
Boston Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 7552:
Mechanisms for Low-Light Therapy V
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

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