
Proceedings Paper
Noise analysis in laser speckle contrast imagingFormat | Member Price | Non-Member Price |
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Paper Abstract
Laser speckle contrast imaging (LSCI) is becoming an established method for full-field imaging of blood flow dynamics
in animal models. A reliable quantitative model with comprehensive noise analysis is necessary to fully utilize this
technique in biomedical applications and clinical trials. In this study, we investigated several major noise sources in
LSCI: periodic physiology noise, shot noise and statistical noise. (1) We observed periodic physiology noise in our
experiments and found that its sources consist principally of motions induced by heart beats and/or ventilation. (2) We
found that shot noise caused an offset of speckle contrast (SC) values, and this offset is directly related to the incident
light intensity. (3) A mathematical model of statistical noise was also developed. The model indicated that statistical
noise in speckle contrast imaging is related to the SC values and the total number of pixels used in the SC calculation.
Our experimental results are consistent with theoretical predications, as well as with other published works.
Paper Details
Date Published: 23 February 2010
PDF: 5 pages
Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630J (23 February 2010); doi: 10.1117/12.842458
Published in SPIE Proceedings Vol. 7563:
Dynamics and Fluctuations in Biomedical Photonics VII
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin, Editor(s)
PDF: 5 pages
Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630J (23 February 2010); doi: 10.1117/12.842458
Show Author Affiliations
Shuai Yuan, Univ. of Maryland, College Park (United States)
Yu Chen, Univ. of Maryland, College Park (United States)
Yu Chen, Univ. of Maryland, College Park (United States)
Andrew K Dunn, The Univ. of Texas at Austin (United States)
David A Boas, Massachusetts General Hospital, Harvard Medical School (United States)
David A Boas, Massachusetts General Hospital, Harvard Medical School (United States)
Published in SPIE Proceedings Vol. 7563:
Dynamics and Fluctuations in Biomedical Photonics VII
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin, Editor(s)
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