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Proceedings Paper

In situ optical property measurement in layered tissue: theoretical and experimental assessment of an unconstrained approach
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Paper Abstract

We have investigated a potential technique based on spatially resolved reflectance to determine optical properties (OPs) in two-layer turbid media. Reflectance from two-layer tissue was simulated for a wide range of OP combinations (μa = 1-22.5, μs' = 5-42.5 cm-1) using a condensed Monte Carlo (MC) model and utilized to train neural network (NN) inverse models. Experimental data from two-layer tissue phantoms with top layer thicknesses (D) ranging from 0.22 to 0.66 mm were collected at three UV-Vis wavelengths. Estimation accuracy was compared to simulated results with added noise. The mean error in experimental determination of μa ranged from 1.5 to 5.9 cm-1 and mean error for μs' ranged from 2.1 to 12.1 cm-1 as a function of D. Although numerous realistic challenges remain, this initial experimental study of an unconstrained two-layer diffuse reflectance based OP estimation approach provides support that such a technique has a strong potential to provide accurate in situ measurements in layered tissues.

Paper Details

Date Published: 24 February 2010
PDF: 7 pages
Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560J (24 February 2010); doi: 10.1117/12.842412
Show Author Affiliations
Quanzeng Wang, U.S. Food and Drug Administration (United States)
T. Joshua Pfefer, U.S. Food and Drug Administration (United States)

Published in SPIE Proceedings Vol. 7556:
Design and Quality for Biomedical Technologies III
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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